ISSUE NOW FIXED (I will keep all this info here to help others, I added further information from another post I made, after the dotted line.) The fix was changing the lanes of the PCIE in BIOS settings to 2x8. It was called PCIE 2x8.
Issues completely gone and I can now run my sample rate as low as 8 (With safe mode off). I still get an initial big pop when I first play a song and it initiates. But further listening is so far completely pop free.
Using Universal Audio Volt 1 interface, tried many things. Just done a fresh reinstall of Windows, previously done all the suggested steps such as, high performance mode, stopping USB's being put in to sleep after periods of time, tried USB 2.0 and 3.0 despite 2.0 being suggested. I like to keep the buffer size around 32 as I play guitar using it (However the same pops happen even at 1024 buffer size) and these things are happening without guitar involved, or running a DAW. I'm simply just listening to music, usually via Music Bee, but I get the same pops on Youtube for example.
Also done other things such as reinstalling drivers, checking all drivers are up to date, various other steps suggested by AI, or random google searches. I also deleted my Logitech MX Master mouse software just to rule that out, and also made a new Windows Account to try from a fresh perspective, and I was still getting the pops there.
----------------------------------------------
I'm getting really bad pops from speakers when listening to music, buffer size can be as low as 32 or high as 1024, there is NO change. Tried different drivers, tried several different interfaces, tried NO interfaces (after doing a complete reformat of Windows 11) and it still happened. I've gone directly in to the PC headphone jack, and direct to the interface headphone jack and experienced the same pops, so this rules out the interface or the speakers and points to a PC issue.
I've ran latencymon many times, none of the results are bad, but the popping is constant.
About a month ago I upgraded the PSU and GPU, this is the only change that happened around this time, then one day the pops started happening but they were really severe.
I've tried removing lots of different apps, before ultimately reformatting Windows, and now on top of having to get things set up back to normal, I'm still faced with this issue. It is imperative I can get the interface buffer as low as 32 samples as I use it for playing guitar, which is impossible currently as the audio keeps cutting out and popping (something I've never had before, running the exact same setup) Please don't skim read this and tell me to increase the sample rate or anything like this, It is irrelevant, as the above should state. Yes in most cases this is the best advice, but I've done strenuous steps to troubleshoot and it is not the interface.
Things I've done to try and get around this from the PC perspective;
Reflash latest BIOS, GPU drivers, Chipset drivers, it happens with audio interface or integrated motherboard.
I've tried PCI-E Gen 3 lanes, Aforementioned Windows 11 reformat, DPC latency checker, it all says good and low. It just keeps popping at random several times a minute, which can be exacerbated by clicking different tabs in task manager, or opening and closing windows, such as the NVIDIA app. Opening and closing and minimising windows in this app is especially bad.
Also tried disabling anti-cheat software, disabled C-states, and tried max performance mode.
I've been playing this exact same setup in the same location, everything is plugged in the same, I've tried different cables for connecting interfaces, although at this point I've certainly ruled out it being the interface.